vaccination

Those who cannot remember the past: how we forgot the first great plague and how we're failing to remember lessons with Ebola

Plague-in-the-Streets.png

“Those who cannot remember the past are condemned to repeat it”

George Santayana

To look at the History of Medicine is to realise how often diseases recur and, sadly, how humans repeat the same mistakes. It is easy to look back with the benefit of hindsight and with modern medical knowledge but we must remember how we remain as fallible as our forebears.

Our first introduction to the History of Medicine is often through learning about the Black Death at school. The story is very familiar; between 1347 and 1351 plague swept the whole of Europe killing between a third and two-thirds of the continent. At the time it was felt the end of the world was coming as a disease never before seen took up to 200 million lives. However, this was actually the second time plague had hit Europe. Nearly a thousand years earlier the first plague pandemic had devastated parts of Europe and the Mediterranean. Half the population of Europe were affected. This was Justinian’s plague, named for the Holy Roman Emperor whose reign the disease helped to define. Yet despite the carnage Europe forgot and had no preparation when plague returned.

Between 2014 and 2016 nearly 30,000 people were hit by the Ebola outbreak in West Africa. Our systems were found lacking as the disease struck in a way never before seen. We said we would learn from our mistakes. Never again.

Yet the current Ebola epidemic in the Democratic Republic of the Congo (DRC) is proving that even today it is hard to remember the lessons of the past and how disease will find any hole in our memory. This is the story of Justinian’s plague, the lessons we failed to learn then and now as we struggle with Ebola.

Justinian’s Plague

Justinian I. Contemporary portrait in the Basilica of San Vitale, Ravenna . From Wikipedia.

It’s 542 CE in Constantinople (now Istanbul). A century earlier the Western provinces of the Roman Empire collapsed. The Eastern empire continues in what will be called the Eastern Roman or Byzantine Empire. Constantinople is the capital city, then as now, a melting pot between Europe and Asia. Since 527 CE this Empire has been ruled by Justian I, an absolute monarch determined to return to the glory years of conquest.

The Empire has already expanded to cover swathes of Northern Africa. Justinian’s focus is now on reclaiming Italy. The Empire is confident and proud, a jewel in an otherwise divided Europe now in the Dark Ages.

The Eastern Roman Empire at the succession of Justinian I (purple) in 527 CE and the lands conquered by the end of his reign in 565 CE (yellow). From US Military Academy.

Procopius of Caesarea (Creative Commons)


The main contemporary chronicler of the plague of Justinian, Procopius of Caesarea (500-565 CE)  identified the plague as arriving in Egypt on the Nile’s north and east shores. From there it spread to Alexandria in the north of Egypt and east to Palestine. The Nile was a major route of trade from the great lakes of Africa to the south. We now know that black rats on board trade ships brought the plague initially from China and India via Africa and the Nile to Justinian’s Empire.


Procopius noted that there had been a particularly long period of cold weather in Southern Italy causing famine and migration throughout the Empire. Perfect conditions to help a disease spread.

In his book Secret History Procopius detailed the symptoms of this new plague: delusions, nightmares, fevers and swellings in the groin, armpits, and behind their ears. For most came an agonising death. Procopius was of no doubt that this was God’s vengeance against Justinian, a man he claimed was supernatural and demonic.

Justinian’s war in Italy helped spread disease but so did peace in the areas he’d conquered. The established trade routes in Northern Africa and Eastern Europe, with Constantinople in the centre, formed a network of contagion. Plague swept throughout the Mediterranean. Constantinople was under siege for four months during which time Procopius alleged 10,000 people died a day in the city. Modern historians believe this figure to be closer to a still incredible 5,000 a day. Corpses littered the city streets. In scenes prescient of the Black Death, mass plague pits were dug with bodies thrown in and piled on top of each other. Other victims were disposed of at sea. Justinian was struck down but survived. Others in Constantinople were not so lucky, in just four months up to 40% of its citizens died.

The plague’s legacy

The plague continued to weaken the Empire, making it harder to defend. Like the medieval kings after him Justinian I struggled to maintain the status quo and tried to impose the same levels of taxation and expansion. He died in 565 CE. His obsession with empire building has led to his legacy as the ‘last Roman’. By the end of the sixth century much of the land in Italy Justinian had conquered had been lost but the Empire had pushed east into Persia. Far from Constantinople the plague continued in the countryside. The plague finally vanished in 750 CE by which point up to 50 million people had died, 25% of the population of the Empire.

Procopius’s description of the Justinian plague sounds like a lot like bubonic plague. This suspicion was confirmed in recent research.

Yersinia pestis bacteria, Creative Commons

At a two separate graves in Bavaria bacterial DNA was extracted from the remains of Justinian plague victims. The DNA matched that of Yersinia pestis the bacterium which causes bubonic plague. The DNA was analysed and found to be most closely related with Y. pestis still endemic to this day in Central Asia. This suggests the route from infection via trade from Asia to Europe.

After 750 CE plague vanished from Europe. New conquerors came and went with the end of the Dark Ages and the rise of the Middle Ages. Europeans forgot about plague. In 1347 they would get a very nasty reminder.

It’s very easy now in our halcyon era of medical advances to feel somewhat smug. Yes, an interesting story but wouldn’t happen now. Medieval scholars didn’t have germ theory. Or a way of easy accessing Procopius’s work. Things are different now.

We’d study Justinian’s plague with its high mortality. We’d identify the cause. We’d work backwards and spot how the trade link with Asia was the route of infection. We’d work to identify potential outbreaks in their early stages in Asia. By the time the second plague epidemic was just starting we’d notice it. There would be warnings to spot disease in travelers and protocols for dealing with mass casualties and disposal of bodies. We’d initiate rapid treatment and vaccination if possible. We’d be OK.

Ebola shows how hard this supposedly simple process remains.

Ebola: A Modern Plague

The Ebola virus (Creative Commons)

Ebola Viral Disease is a type of viral haemorrhagic fever first identified in 1976 during an outbreak in what is now South Sudan and the DRC. Caused a spaghetti-like virus known as a filovirus this disease causes severe dehydration through vomiting and diarrhoea before internal and external bleeding can develop. Named for the Ebola River where it was first identified it spreads by direct human contact with a mortality rate varying from 25% to 90%. An epidemic has been ongoing in DRC since August 2018. We are in our fourth decade of knowing about Ebola. And five years ago we were given the biggest warning yet about its danger.

Up until 2014 the largest outbreak of Ebola had affected 315 people. Other outbreaks were much smaller. Ebola seemed to burn brightly but with only a few embers. In 2014 it became a forest fire.

A healthcare worker during the Ebola outbreak of 2014-16 (From CNN.com)

The West Africa Epidemic of 2014-16 hit Guinea, Sierra Leone and Liberia. The disease showed its potential in our age of global travel as the first cases appeared in America and Europe. In all there were 28,160 reported cases. 11,308 people died. Ebola caught the world napping. What had been a rare disease of Africa was potentially a threat to us all. Suspicion of foreign healthcare workers and miscommunication about the causes of Ebola were blamed for helping to further the disease. Yet there was hope as promising experimental vaccines were put into production.

As the forest fire finally died down there was a chance to reflect. There were many publications, including from Médecins sans frontières, about the lessons learnt from Ebola and how not to repeat the lessons from the past. These were all along similar themes: the importance of trained frontline staff, rapid identification of the disease, engaging and informing local communities, employing simple yet effective methods to provide disease spread and the use of the new vaccine to protect contacts and contacts of contacts. There was lots of criticism about the speed of the World Health Organisation response but also a feeling that with new tools and lessons learnt things would be different next time.

When Ebola surfaced again last year in the DRC there was initial hope that lessons were learnt. Over 100,000 people have been vaccinated; a new weapon. However, the disease continues a year on with over 1000 cases and over 800 fatalities and fresh concern that this outbreak is far from over.

There remains delays in identifying patients with Ebola; not surprising as the early symptoms mimic more common diseases such as malaria. As a result patients are not isolated quickly enough and may infect others before their test results are back. Also the talk of engaging communities is falling flat. In a region torn apart by decades of civil unrest there is widespread mistrust of authorities with blame falling on the Ebola units themselves for causing death. It is estimated that 30% of patients are staying at home and being a potent vector for disease rather than coming forward. There has also been violence against healthcare workers and hospitals as a result of this fear. Reassuringly, where local communities and healthcare has come together Ebola has been stopped but this is not the norm and behavioural scientists are being used to help connect with locals. Despite the lessons learnt Ebola is continuing to be a difficult adversary.

It is easy in the West to feel we are immune from misinformation and fear. Yet look at the current measles epidemic in New York State. Look at the anti-vaccination movement, labelled a “public health timebomb” by Simon Stevens, the chief executive of NHS England last week. We are no more immune than anyone else to irrationality. Nor too proud to learn the lessons of the past; the ‘ring’ style of vaccinating contacts against Ebola is the same as used during the successful campaign to eradicate smallpox over four decades ago.

Medical advances have come on in ways no-one in the Middle Ages could have foreseen. We have never had more ways to share our knowledge of disease or so many ways to prevent suffering. Yet people remain the same. And that’s the tricky part. Let’s not forget that bit.

Thanks for reading

- Jamie

There is nothing new under the sun: the current New York measles epidemic and lessons from the first 'anti-vaxxers'

An 1807 cartoon showing ‘The Vaccination Monster’

What has been will be again,
    what has been done will be done again;
    there is nothing new under the sun.

Ecclesiastes 1:9

The State of New York is currently in the midst of an epidemic. Measles, once eradicated from the USA has returned with a vengeance. Thanks to a rise in unvaccinated children fueled by the ‘anti-vaxxer’ movement 156 children in Rockwood County have been infected by measles; 82.8% of these had never had even one MMR vaccine. With measles now rampant in the boroughs of Brooklyn and Queens the state government has taken an unusual step. In New York in the USA, the home of liberty and personal choice, no unvaccinated under-18 year old is now able to set foot in a public space. Parents of unvaccinated children who break this ban will face fines or jail.

In a previous blog I wrote about the fight against smallpox first using variolation (which sometimes caused infection) and then the invention of the world’s first vaccine. This musing is about how vaccination was made compulsory in the United Kingdom, the subsequent fight against it through a public campaign and how that movement raised its head again in the last few decades. This is the story of the first ‘anti-vaxxer’ movement and how the arguments regarding vaccination show there isn’t really anything new under the sun.

Early opposition to vaccination

Following Edward Jenner’s work into using cowpox to offer immunity against smallpox in 1796 the Royal Jennerian Society was established in 1803 to continue his research.

Even in these early days there was opposition to the vaccine. John Birch, the ‘surgeon extraordinary’ to the Prince of Wales pamphleteered against Jenner’s work with arguments one might expect to see circulating today on social media:

A section of John Birch’s pamphlet from https://vaxopedia.org/2017/10/07/who-was-john-birch/

He of course did not mention how he was making a lot of money through inoculating patients against smallpox (a practice that vaccination would replace) or using novel treatments such as electrocution.

Wood painting caricature from 1808 showing Edward Jenner confronting opponents to his vaccine (note the dead at their feet) (Creative Commons)

Despite Birch’s efforts by 1840 the efficacy of Jenner’s vaccine was widely accepted. Decades before germ theory was established and viruses were identified we finally had a powerful weapon against a deadly disease. Between 1837 and 1840 a smallpox epidemic killed 6,400 people in London alone. Parliament was persuaded to legislate. The 1840 Vaccination Act made the unpredictable variolation illegal and made provision for free, optional smallpox vaccination.

At the time healthcare in the UK was largely unchanged since Tudor times. Parish based charity had been the core of support for the sick and poor until workhouses were made the centre of welfare provision in 1834. With the workhouse came a stigma that illness and poverty were avoidable and to be punished. Government was dominated by two parties, the Whigs and the Tories both of whom were non-interventionist and the universal healthcare provided by the NHS was over a century away. Consider this laissez-faire backdrop with punitive welfare. The fact free vaccination was provided is remarkable and I think reflects the giddy optimism at a future without ‘the speckled monster’ of smallpox.

The Anti-Vaccination Leagues

The Vaccination Act of 1853 went further. Now vaccination against smallpox was compulsory for all children born after 1st August 1853 within the first three months of their life with fines for parents who failed to comply. By the 1860s two-thirds of babies in the UK had been vaccinated.

There was immediate opposition to the 1853 Act with violent protests across the country. This was the state’s first steps into the health of private citizens. The response seems to have been motivated in much the same way as the modern day opposition in the US to vaccination and universal healthcare in general: that health is a matter of private civil liberty and that vaccination caused undue distress and risk. In England and Wales in particular although the penalties were rarely enacted their presence alone seems to have been motivation for opposition. The Anti-Vaccination League in London was established in 1853 to allow dissenting voices to coalesce.

The Vaccination Act of 1867 extended the age by which a child had to be vaccinated to 14 with cumulative fines to non-compliance. That same year saw the formation of the Anti-Compulsory Vaccination League. They published the National Anti-Compulsory Vaccination Reporter newsletter in which they listed their concerns, the first three being:

I. It is the bounden duty of parliament to protect all the rights of man.

II. By the vaccination acts, which trample upon the right of parents to protect their children from disease, parliament has reversed its function.

III. As parliament, instead of guarding the liberty of the subject, has invaded this liberty by rendering good health a crime, punishable by fine or imprisonment, inflicted on dutiful parents, parliament is deserving of public condemnation.

Further newsletters were formed over the following decades: the Anti-Vaccinator (founded 1869), the National Anti-Compulsory Vaccination Reporter (1874), and the Vaccination Inquirer (1879). All of these continued to place political pressure against compulsory vaccination. Much like today the main body of arguments focused on personal choice and the testimony of parents alleging that their child was injured or killed by vaccination. In Leicester in 1885 an anti-vaccination demonstration attracted 100,000 people. A staggering number when the city’s population in total at the time was around 190,000.

A royal commission was called to advise on further vaccination policy. After deliberation for seven years listening to evidence across the spectrum of opinion in 1896 they published their findings. Smallpox vaccination was safe and effective. However, it advised against continuing compulsory vaccination. Following the 1898 Vaccination Act parents who did not want their child to be vaccinated could ‘conscientiously object’ and be exempt. There was no further appetite for Parliament to intervene in the rights of parents. Even the fledgling socialist Labour Party, no enemy of government intervention, made non-compulsory vaccination one of its policies.

Whilst the two World Wars saw a change in public opinion towards a greater role in society for government, culminating in the creation of the National Health Service in 1948, vaccination remains voluntary in the United Kingdom. The first half of the 20th century saw the advent of vaccines against several deadly diseases such as polio, measles, diphtheria and tetanus. In 1966 an ambitious worldwide vaccination programme led by the World Health Organisation saw smallpox become the first disease to be eradicated by mankind in 1980. There were dreams of polio and measles going the same way. It was not to be.

Anti-vaccination re-emerges

Herd immunity is a key component for any vaccination programme to be effective. Not everyone can be vaccinated and so they rely on being surround by vaccinated people to prevent transmission. The level of vaccination in a population required for herd immunity varies between diseases. The accepted standard to prevent measles transmission is 90-95%.

On 28th February 1998 an article was published in the Lancet which claimed that the Measles, Mumps and Rubella (MMR) vaccine was linked to the development of development and digestive problems in children. Its lead author was Dr Andrew Wakefield, a gastroenterologist.

The infamous Lancet paper linking the MMR vaccine to developmental and digestive disorders

The paper saw national panic about the safety of vaccination. The Prime Minister Tony Blair refused to answer whether his newborn son Leo had been vaccinated.

Except just like John Birch nearly two centuries before him Andrew Wakefield had held a lot back from the public and his fellow authors. He was funded by a legal firm seeking to prosecute the companies who produce vaccines. This firm led him to the parents who formed the basis of his ‘research’. The link between children developing developmental and digestive problems was made by the parents of twelve children recalling that their child first showed their symptoms following the MMR vaccine. Their testimony and recall alone were enough for Wakefield to form a link between vaccination and autism. From a research sense his findings were no more useful than those the Victorian pamphlets used. But the damage was done. The paper was retracted in 2010. Andrew Wakefield was struck off as were some of his co-authors who did not practice due diligence. Sadly, this has only helped Wakefield’s ‘legend’ as he tours America spreading his message tapping in to the general ‘anti-truth’ populist movement. Tragically unsurprisingly, often in his wake comes measles.

Earlier this year the largest study to date investigating the links between MMR and autism was published. 657,461 children in Denmark were followed up over several years (compare that to Wakefield’s research where he interviewed the parents of 12 children). No link between the vaccine and autism was shown. In fact, no large high level research has ever backed up Wakefield’s claim.

There are financial and political forces at work here. Anti-vaccination is worth big money. The National Vaccination Information Center in the US had an annual income of $1.2 billion in 2017. And the people they target are economically and politically powerful. Recent research in America shows that parents who refuse vaccinations for their children are more likely to be white, educated and of higher income. They prize purity and liberty above all, emotional reasoning over logic. They vote. And their world view is prevalent in certain circles.

Tweet by Donald Trump 28th March 2014

Tweet by Donald Trump 28th March 2014

In the UK in 2018 the rate of MMR vaccination was 91.8%, worryingly close to no longer being effective for herd immunity. There have been debates in the UK about re-introducing compulsory vaccination. In France certain childhood vaccinations are now compulsory. Social media companies are under pressure to silence the groups anti-vaxxers use to spread their message and recruit. The state is once again prepared to step into personal liberty when it comes to vaccines.

In 1901 52% of childhood deaths in England and Wales were due to infectious diseases. By 2000 it was 7.4%. In 1901 40.6% of all deaths were children. By 2000 it was 0.9%. No-one would want that progress to reverse. But history does have a habit of repeating itself if we let it. The debates continue to be the same: the rights of parents and the individual versus those of the state and public health necessity. This is a debate we have to get right. History tells us what will happen if we don’t. After all, there is nothing new under the sun.

Thanks for reading

- Jamie

Smallpox: the Giants' Shoulders Edward Jenner Stood on to Overcome 'The Speckled Monster'

Convergent evolution is a key principle in Biology. Basically, it means that nature will find the same ‘solutions’ for organisms filling similar environmental niches. So in different species with no close relation but who encounter similar environments (say sharks and dolphins) you’ll see similar features (both have fins). The same is true in the history of science. Very few discoveries are actually made in solitude; more often there were several people working on the same problem but often only one gets the fame. For Charles Darwin see Alfred Russel Wallace. For Sir Isaac Newton see Robert Hooke.

When it comes to vaccination and the conquest of smallpox, one of the most deadly diseases to ever afflict mankind, one name always comes to mind: Edward Jenner. We all know the story: an English country doctor in the 18th century observed how milkmaids who contracted cowpox from their cattle were immune to the far more serious smallpox. On 14th May 1796 he deliberately infected the eight-year-old boy James Phipps with cowpox. The boy develops a mild fever. Later Jenner exposes Phipps to pus from a smallpox blister. The boy is unaffected by smallpox. A legend is born. Vaccination becomes the mainstay of the fight against smallpox. In the 20th century a worldwide campaign results in smallpox being the first disease to be eradicated.

Of course, as we all know, things are rarely this straightforward and there are many less famous individuals who all contributed to the successful fight against smallpox.

Dr Jenner performing his first vaccination on James Phipps, a boy of age 8. May 14th, 1796. Painting by Ernest Board (early 20th century).

Smallpox, the ‘speckled monster’, has a mortality rate of 30% and is caused by a highly contagious airborne virus. It long affected mankind; smallpox scars have been seen in Egyptian mummiesfrom the 3rd Century BCE. Occurring in outbreaks it is estimated to have killed up to 500 million peoplein the 20th century alone. Throughout history it was no respecter of status or geography, killing monarchs and playing a role in the downfall of indigenous peoples around the world. Superstition followed smallpox with the disease even being worshipped as a god around the world.

Doctors in the West had no answer to it. But in other parts of the world solutions were found. With colonisation and exploration the West started to hear about them. More than seventy years before Jenner’s work two people on either side of the Atlantic were inspired by custom from Africa and Asia. 

Left: Shitala, the North Indian goddess of pustules and sores

Right: Sopona, the god of smallpox in the Yoruba region of Nigeria

Lady Mary Wortley Montagu


In 1721 in London Lady Mary Wortley Montagu the wife of the Ambassador to Turkey who had lost her brother to smallpox having survived the disease herself is keen to protect her daughter. Whilst in Turkey she learned of the local practice of ‘variolation’ or inoculation against smallpox. Pus from the pustules of patients with mild smallpox is collected and scratched into the skin of an uninfected person. This was a version of a process dating back to circa 1000 AD in China where pustule material was blown up the nose of a patient. Mary was impressed and her son was inoculated in Turkey in 1715. 

Six years later in London her daughter was similarly inoculated in the presence of doctors of the royal court, the first such procedure in Britain. She campaigns for the practice to be spread.

Cotton Mather

Also in 1721, an outbreak of smallpox is ravaging Boston, Massachusetts. An influential minister Cotton Mather is told by one of his African slaves, Onesimus, about a procedure similar to inoculation. According to Onesimus as a younger man a cut was made into his skin and smallpox pustules were rubbed into the wound. He told Mather that this had made him immune to smallpox. Mather hears of the same practice in China and Turkey and is intrigued. He finds a doctor, Zabdiel Boylston, and the two start performing the first inoculations in America.

Lady Wortley Montagu and Cotton Mather never met, they lived on opposite sides of the Atlantic and yet learnt of the same practice. Convergent medical advances in practice.

Inoculation is not without risk however and Prince Octavius, son of King George III dies in 1783 following inoculation. People inoculated with smallpox are also potentially contagious. An alternative is sought.

In 1768 an English physician John Fewster identified that cowpox offered immunity against smallpox and begins offering the practice of immunisation. In 1774 Benjamin Festy, a dairy farmer in Yetminster, Dorset, also aware of the immunity offered by cowpox,, has his wife and children infected with the disease. He tests the procedure by then exposing his son to smallpox. His son is fine. The process is called vaccination after the Latin word for cow. However, neither men publish their work. In France in 1780 politician Jacques Antoine Rabaut-Pommier opens a hospital and offers vaccination against smallpox. It is said that he told an English doctor called Dr Pugh about the practice. The English physician promised to tell his friend, also a doctor, about vaccination. His friend’s name? Edward Jenner.

It is Jenner who publishes his work and pushes for vaccination as a preventative measure against smallpox. It is his vaccine which is used as the UK Parliament through a succession of Acts starting in 1840 makes variolation illegal and provides free vaccination against smallpox. In a precursor of the ignorance of the ‘anti-vaxxer’ movement there is some public hysteria but vaccination proves safe and effective (as it still is).

Cartoon by British satirist James Gillray from 1802 showing vaccination hysteria

Arguably, without Jenner’s work such an effective campaign would have been held back. As the American financier Bernard Baruch put it, “Millions saw the apple fall, but Newton was the one who asked why.” However, Newton himself felt that “if I have seen further it is because I have stood on the shoulders of giants.” History in the West has a habit of focusing on rich white men at the exclusion of others, especially women and slaves. Any appreciation of Jenner’s work must also include those giants whose shoulders he stood by acknowledging the contribution of people like Lady Wortley Montagu and Onesimus and of Fewster and Festy - the Wallaces to his Darwin.

Thanks for reading

- Jamie