Public Health

Bullet Holes & Bias: The Story of Abraham Wald

“History is written by the victors”

Sir Winston Churchill

It is some achievement if we can be acknowledged as succeeding in our field of work. If that field of work happens to be helping to win the most bloody conflict in history then our achievement deserves legendary status. What then do you say of a man who not only succeeded in his field and helped the Allies win the Second World War but whose work continues to resonate throughout life today? Abraham Wald was a statistician whose unique insight echoes in areas as diverse as clinical research, finance and the modern celebrity obsession. This is his story and the story of survivorship bias. This is the story of why we must take a step back and think.

Abraham Wald and Bullet Holes in Planes

Wald was born in 1902 in the then Austria-Hungarian empire. After graduating in Mathematics he lectured in Economics in Vienna. As a Jew following the Anschluss between Nazi Germany and Austria in 1938 Wald and his family faced persecution and so they emigrated to the USA after he was offered a university position at Yale. During World War Two Wald was a member of the Statistical Research Group (SRG) as the US tried to approach military problems with research methodology.

One problem the US military faced was how to reduce aircraft casualties. They researched the damage received to their planes returning from conflict. By mapping out damage they found their planes were receiving most bullet holes to the wings and tail. The engine was spared.

DISTRIBUTION OF BULLET HOLES IN AIRCRAFT THAT RETURNED TO BASE AFTER MISSIONS. SKETCH BY WALD. IN “VISUAL REVELATIONS” BY HOWARD WAINER. LAWRENCE ERLBAUM AND ASSOCIATES, 1997.

Abraham Wald

The US military’s conclusion was simple: the wings and tail are obviously vulnerable to receiving bullets. We need to increase armour to these areas. Wald stepped in. His conclusion was surprising: don’t armour the wings and tail. Armour the engine.

Wald’s insight and reasoning was based on understanding what we now call survivorship bias. Bias is any factor in the research process which skews the results. Survivorship bias describes the error of looking only at subjects who’ve reached a certain point without considering the (often invisible) subjects who haven’t. In the case of the US military they were only studying the planes which had returned to base following conflict i.e. the survivors. In other words what their diagram of bullet holes actually showed was the areas their planes could sustain damage and still be able to fly and bring their pilots home.

No matter what you’re studying if you’re only looking at the results you want and not the whole then you’re subject to survivorship bias.

No matter what you’re studying if you’re only looking at the results you want and not the whole then you’re subject to survivorship bias.

Wald surmised that it was actually the engines which were vulnerable: if these were hit the plane and its pilot went down and didn’t return to base to be counted in the research. The military listened and armoured the engine not the wings and tail.

The US Airforce suffered over 88,000 casualties during the Second World War. Without Wald’s research this undoubtedly would have been higher. But his insight continues to this day and has become an issue in clinical research, financial markets and the people we choose to look up to.

Survivorship Bias in Clinical Research

In 2010 in Boston, Massachusetts a trial was conducted at Harvard Medical School and Beth Israel Deaconess Medical Center (BIDMC) into improving patient survival following trauma. A major problem following trauma is if the patient develops abnormal blood clotting or coagulopathy. This hinders them in stemming any bleeding they have and increases their chances of bleeding to death. Within our blood are naturally occurring proteins called factors which act to encourage blood clotting. The team at Harvard and BIDMC investigated whether giving trauma patients one of these factors would improve survival. The study was aimed at patients who had received 4-8 blood transfusions within 12 hours of their injury. They hoped to recruit 1502 patients but abandoned the trial after recruiting only 573.

Why? Survivorship bias. The trial only included patients who survived their initial accident and then received care in the Emergency Department before going to Intensive Care with enough time passed to have been given at least 4 bags of blood. Those patients who died prior to hospital or in the Emergency Department were not included. The team concluded that due to rising standards in emergency care it was actually very difficult to find patients suitable for the trial. It was therefore pointless to continue with the research.

This research was not the only piece reporting survivorship bias in trauma research. Does this matter? Yes. Trauma is the biggest cause of death worldwide in the under 45 year-olds. About 5.8 million people die worldwide due to trauma. That’s more than the annual total of deaths due to malaria, tuberculosis and HIV/AIDS. Combined. Or, to put it another way, one third of the total number of deaths in combat during the whole of the Second World War. Every year. Anything that impedes research into trauma has to be understood. Otherwise it costs lives. But 90% of injury deaths occur in less economically developed countries. Yet we perform research in Major Trauma Units in the West. Survivorship bias again.

As our understanding of survivorship bias grows so we are realising that no area of Medicine is safe. It clouds outcomes in surgery and anti-microbial research. It touches cancer research. Cancer survival rates are usually expressed as 5 year survival; the percentage of patients alive 5 years after survival. But this doesn’t include the patients who died of something other than cancer and so may be falsely optimistic. However, Medicine is only a part of the human experience survivorship bias touches.

Survivorship Bias in Financial Markets & our Role Models

Between 1950 and 1980 Mexico industrialised at an amazing rate achieving an average of 6.5% growth annually. The ‘Mexico Miracle’ was held up as an example of how to run an economy as well as encouraging investment into Latin American markets. However, since 1980 the miracle has run out and never returned. Again, looking only at the successes and not the failures can cost investors a lot of money.

Say I’m a fund manager and I approach you asking for investment. I quote an average of 1.8% growth across my funds. Sensibly you do your research and request my full portfolio:

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It is common practice in the fund market to only quote active funds. Poorly performing funds, especially those with negative growth, are closed. If we only look at my active funds in this example then yes, my average growth is 1.8%. You might invest in me. If however you look at all of my portfolio then actually my average performance is -0.2% growth. You probably wouldn’t invest then.

Yet survivorship bias has a slight less tangible effect on modern life now. How often is Mark Zuckerberg held up as an example for anyone working in business? We focus on the one self-made billionaire who dropped out of education before making their fortune and not the thousands who followed the same path but failed. A single actor or sports star is used as a case study on how to succeed and we are encouraged to follow their path never mind that many who do fail. Think as well about how we look at other aspects of life. How often do we look at one car still in use after 50 years or one building still standing after centuries and say, “we don’t make them like they used to”? We overlook how many cars or buildings of a similar age have now rusted or crumbled away. All of this is the same thought process going through the minds of the US Military as they counted bullet holes in their planes.

To the victor belong the spoils but we must always remember the danger of only looking at the positive outcomes and ignoring those often invisible negatives. We must be aware of the need to see the whole picture and notice when we are not. With our appreciation of survivorship bias must also come an appreciation of Abraham Wald. A man whose simple yet profound insight shows us the value of stepping back and thinking.

Thanks for reading

- Jamie

The Most Famous Case Report Ever

Case reports are nothing new. We’ve all told colleagues about interesting cases we’ve seen. I’ve presented a couple at RCEM. They tend to focus on the weird and wonderful, cases with surprising twists and turns but with actual limited learning. That’s why case reports are at the bottom of the table when it comes to levels of evidence. However, one in particular could be said to have marked a turning point in modern medical practice.

The Morbidity and Mortality Weekly Report (MMWR) has been published weekly by the Centre for Disease Control and Prevention (CDC) since 1950. Each week they release public health information, possible exposures, outbreaks and other health risks for health workers to be aware of. One case report in particular stands out out of all of their back catalogue. It was written by various doctors from the University of California, Los Angeles and Cedars-Mt Sinai Hospital, Los Angeles. It was published on June 5th 1981:

The MMWR June 5th 1981

Reported by MS Gottlieb, MD, HM Schanker, MD, PT Fan, MD, A Saxon, MD, JD Weisman, DO, Div of Clinical Immunology-Allergy, Dept of Medicine, UCLA School of Medicine; I Pozalski, MD, Cedars-Mt. Sinai Hospital, Los Angeles; Field Services Div, Epidemiology Program Office, CDC.

Pneumocystis Pneumonia (PCP) is a rare form of pneumonia caused by the yeast like fungus Pneumocystis jiroveci. The fungus can live in the lungs of healthy people without causing any problems so to see it in 5 otherwise healthy young (the oldest was 36) people was odd.

Less than a month later the MMWR published further cases of PCP as well as Kaposi sarcoma in 26 previously well homosexual men in Los Angeles and New York since 1978. Kaposi sarcoma is very rare form of cancer previously seen usually in older men of Jewish/Mediterranean descent. Again it was virtually unheard of it in young men. It was suspected that something was affecting their immune systems preventing them from fighting off infections and malignancy.

At the time there were many theories as to what was causing the immune systems of patients to shut down. It was felt that it was linked to the ‘gay lifestyle’ in some way leading to the stigmatising description in the media of GRID (Gay-related immunodeficiency) first used in 1982. By 1983 the disease was linked also to injecting drug users, haemophiliacs who’d received blood products and Haitians. This led to another stigmatising phrase ‘the 4H club’ (Homosexuals, Heroin addicts, Haemophiliacs and Haitians).

In 1982 however, the CDC had actually given it a proper name: ‘Acquired Immune Deficiency Syndome’ or ‘AIDS’.

The fact it was being transmitted to blood product recipients suggested the cause had to be viral as only a virus could pass the filtration process. In 1983 two rival teams, one American and one French, both announced they had found the virus causing AIDS with ongoing debate as to who got there first. Each team gave it a different name. In 1985 a third one was chosen: ‘Human Immunodeficiency Virus’ or ‘HIV’. By that time the virus had spread not just in America but in Canada, South America, Australia, China, the Middle East and Europe. Since 1981 worldwide more than 70 million people have been infected with the HIV virus and about 35 million people have died of AIDS. 

The MMWR of 5th June 1981 is now recognised both as the beginning of the HIV/AIDS pandemic and as the first publication of HIV/AIDS. Although only a case report it shows the value of these publications at the front line. Only by recording and publishing the ‘weird and wonderful’ can we start to share practice, appreciate patterns and spot emergent diseases.

Thanks for reading

- Jamie

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We Need to Talk About Kevin: Is Kevin McCallister a Psychopath?

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It’s Christmas time, there’s no need to be afraid. At Christmas time we let in light and we banish shade. And usually sit down to watch a number of Christmas films including one or both of Home Alone (1990) or Home Alone 2: Lost in New York (1992)*. Both films were written and produced by John Hughes and directed by Chris Colombus and star Macaulay Culkin as Kevin McCallister as a young boy left home at Christmas in the first film and who ends up in New York in the second. In both he has to defend himself against a couple of bumbling burglars ‘The Wet Bandits’, Harry (Joe Pesci) and Marv (Daniel Stern). Home Alone remains the highest grossing live action comedy in the US and only lost the worldwide title in 2011 to The Hangover II. Both films are firm fixtures for Christmas watching.

Yet, on a recent viewing the other day there was an easy question in my mind. Not the sad decline of Macaulay Culkin from childhood star to example for any child who becomes famous or even the fact that the McCallister family would clearly have social services swarming over them. No, this question was about the character of Kevin himself. Beyond all the jokes and slapstick, is Kevin McCallister a psychopath?

I’m not a psychiatrist so I first had to look up the criteria to make a diagnosis. Turns out psychopathy doesn’t really exist anymore as a diagnosis and has been largely replaced by anti-social personality disorder (ASPD). So this changed my question for this musing immediately; does Kevin McCallister fulfil the criteria for ASPD?

As Kevin McCallister is American it seemed right to base any diagnosis against the criteria of the American Psychiatric Association. Fortunately, they publish their diagnostic criteria in the Diagnostic and Statistical Manual of Psychiatric Disorders (DSM) now in its 5th iteration published in 2013. The DSM defines the essential features of a personality disorder as “impairments in personality (self and interpersonal) functioning and the presence of pathological personality traits.” The DSM 5 details very clear criteria to make a diagnosis of ASPD.

First there needs to be significant impairments in self functioning AND in interpersonal functioning.

DSM defines impairments in self functioning as either identity or self-direction:

a.Identity: Ego-centrism; self-esteem derived from personal gain, power, or pleasure.

b.Self-direction: Goal-setting based on personal gratification; absence of prosocial internal standards associated with failure to conform to lawful or culturally normative ethical behaviour.

Kevin certainly has high self-esteem. In Home Alone he genuinely believes that through his own power he has made his own family disappear. A belief that prompts celebration:

In terms of conforming to legal or ethical behaviour at no point in either film does he seek to tell the police or authorities that he’s home alone or at risk of the Wet Bandits. Indeed, he shop lifts albeit inadvertently in the first film and uses his father’s credit card to book into a luxury hotel in the second. He certainly uses his freedom for personal gratification spending $967 ($1,742.98 in today’s money) on room service alone in Home Alone 2.

So far it seems like he’s ticking the boxes without us even mentioning the vigilante justice. More of that violence later.

On to interpersonal functioning, defined by the DSM as either in empathy or intimacy:

a.Empathy: Lack of concern for feelings, needs, or suffering of others; lack of remorse after hurting or mistreating another.

b.Intimacy: Incapacity for mutually intimate relationships, as exploitation is a primary means of relating to others, including by deceit and coercion; use of dominance or intimidation to control others.

Speaking as a doctor in Emergency Medicine let’s get this straight: Kevin would have killed the Wet Bandits several times over. Especially in the second film where to start he throws four bricks on Marv’s head from height. Marv would be dead. No question. Kevin McCallister is attempting murder:

Later on, he sets up elaborate traps and stays around rather than running away (like most would do) merely to supervise Marv getting electrocuted and Harry setting fire to his head:

At no stage does he show any remorse and actually celebrates what he’s doing. Prior to meeting Kevin the Wet Bandits were cartoon villains, non-violent and stupid. Did they deserve to die? Kevin obviously felt it was worth risking it and enjoyed it.

He does form friendships in both films with people he previously feared; Old Man Marley and the Pigeon Lady. He inspires the former to re-connect with his family and gives the latter a present. This does suggest that he can form bonds with people. However, both were useful to him by helping him escape the Wet Bandits so it could be argued he was exploiting and rewarding them for his own benefit. This bit is open to debate but for the benefit of the blog lets assume this was Machiavellian manipulation and move on.

The patient then needs to have pathological personality traits in antagonism and disinhibition.

The DSM defines antagonism as:

a.Manipulativeness: Frequent use of subterfuge to influence or control others; use of seduction, charm, glibness, or ingratiation to achieve one„s ends.

b.Deceitfulness: Dishonesty and fraudulence; misrepresentation of self; embellishment or fabrication when relating events.

c. Callousness: Lack of concern for feelings or problems of others; lack of guilt or remorse about the negative or harmful effects of one’s actions on others; aggression; sadism.

d. Hostility: Persistent or frequent angry feelings; anger or irritability in response to minor slights and insults; mean, nasty, or vengeful behaviour.

We’ve already looked at Kevin’s violence and cruelty. He’s also certainly a master of deception. Throughout both films he is adept at speaking to adults and painting stories with great ease. Lying comes very easily to him as does using props and music whether to pretend to be his dad in the shower, a gangster with a gun or even a house full of celebrating people:

This is a crafty kid who is willing to lie and smile while doing it.

Disinhibition is defined by the DSM as:

a. Irresponsibility: Disregard for – and failure to honor – financial and other obligations or commitments; lack of respect for – and lack of follow through on – agreements and promises.

b. Impulsivity: Acting on the spur of the moment in response to immediate stimuli; acting on a momentary basis without a plan or consideration of outcomes; difficulty establishing and following plans.

c.Risk taking: Engagement in dangerous, risky, and potentially self-damaging activities, unnecessarily and without regard for consequences; boredom proneness and thoughtless initiation of activities to counter boredom; lack of concern for one’s limitations and denial of the reality of personal danger

In both films Kevin shows poor regard for his own safety, whether climbing down a rope soaked in kerosine, zip-lining from the roof of his house or climbing his brother’s shelves:

Early on in both films he is shown impulsively lashing out in anger when he feels frustrated at having his pizza eaten or embarrassed in public during his choir solo. Kevin is not inhibited:

And violence is clearly natural to him. So far…seems to be meeting all the criteria.

Finally these factors must be consistent across time and place. They must not be due to intoxication or head injury.

As Kevin behaves the same in Home Alone (1990, set in Chicago) and Home Alone 2 (1992, set in New York) we can assume his behaviour is consistent to time and place. At no point is he seen taking drugs or drinking alcohol so we can rule those out as a cause. He does hit his head slipping on ice in Home Alone 2 but that’s very late on and isn’t shown to effect his behaviour in any way. Once again he’s meeting criteria.

They must not be better understood as “normative for the individual’s developmental stage or socio- cultural environment.”

Kevin is a remarkable child acting in a way we wouldn’t expect of a boy his age. He definitely has, at best, a chaotic family and there’s no doubt that after Home Alone 2 social services would have come down on the McCallister family like a tonne of bricks:

However, the house is pristine and all the children look well nourished and dressed. While there’s plenty of questions about what kind of job the McCallisters must do in order to fund this lifestyle there’s no indication that this is a family where violence is the norm. Box ticked again.

Finally, the individual is at least age 18 years.

Ah, here it falls down right at the last. Kevin is 8 in Home Alone and so well below the age where we can diagnose ASPD. NICE does have a Quality Standard (QS59) first published in 2014 aimed at identifying children at risk of ASPD. This includes interventions for the whole family. But in no way can a conclusive diagnosis be made in a child.

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So is Kevin McCallister a psychopath? By the DSM diagnostic criteria the answer is no. Does he show some traits that might set off alarm bells? The answer is yes. However, there is a debate about whether ‘psychopathy’ is an evolved trait which has been able to survive through natural selection as it has benefited human society to have individuals without morals prepared to do whatever it takes to achieve their goals (Glenn, Kurzban and Raine, 2011). Maybe we should celebrate Kevin’s innate traits as he uses them to defend himself and his family. After all, it means the bad guys get caught and it wouldn’t really make good films if he just rang the police like a good citizen.

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Time to be serious now. This blog does highlight a big issue I find with mental health. Almost ahead of any other profession people are all too willing to play ‘keyboard psychiatrist’ and diagnose public figures such as Donald Trump with a mental illness. Whilst this blog is meant as a bit of fun it shows how mental health has very clear diagnostic criteria to be met before we use loaded terms such as ‘psychopath’. That can be my Christmas message: before you make a stigmatising diagnosis make sure you know what you’re talking about. In fact in general: research first, speak later. Let’s be nice people.

Merry Christmas, you filthy animals

*Yes, I am aware there is a ‘Home Alone 3’ and even somethings called Home Alone 4: Taking Back the House and Home Alone: The Holiday Heist. I just choose to ignore them as we all should.

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REFERENCES:

Glenn, A., Kurzban, R. and Raine, A. (2011). Evolutionary theory and psychopathy. Aggression and Violent Behavior, 16(5), pp.371-380.

Hopwood, C. J., Thomas, K. M., Markon, K. E., Wright, A. G., & Krueger, R. F. (2012). DSM-5 personality traits and DSM-IV personality disorders. Journal of abnormal psychology121(2), 424-32.